Table 3

Changes in selected lipoprotein subclass measurements and standard plasma lipid profiles by gender

Controls (n = 73)

Participants (n = 73)


Variable

Gender

Baseline

Week 12

Week 52

% change

Baseline

Week 12

Week 52

% change

Between group

p valuea


VLDL particles

Large VLDL/chylomicrons

F

5.7 ± 7.7

6.1 ± 7.4

5.0 ± 6.0

-12.4

7.9 ± 7.0

5.9 ± 6.2

8.1 ± 8.5

+3.0

0.62

M

3.6 ± 4.5

4.4 ± 5.0

4.1 ± 4.9

+14.5

8.4 ± 6.8

3.6 ± 4.1b

3.7 ± 4.7b

-55.9

< 0.01

LDL particles

Total LDL particles

F

1364 ± 388

1376 ± 500

1347 ± 475

-1.3

1478 ± 497

1356 ± 460

1388 ± 516

-6.1

0.42

M

1156 ± 323

1126 ± 302

1163 ± 335

+0.6

1401 ± 463

1234 ± 430c

1256 ± 385c

-10.4

0.03

Small LDL particles

F

902 ± 491

914 ± 548

924 ± 534

+2.4

1076 ± 565

1046 ± 485

1048 ± 568

-2.6

0.63

M

843 ± 382

834 ± 334

857 ± 381

+1.7

1145 ± 393

1006 ± 385c

972 ± 368c

-15.1

< 0.01

LDL size

F

20.9 ± 0.9

20.9 ± 0.9

20.8 ± 0.9

-0.4

20.5 ± 0.9

20.4 ± 0.7

20.5 ± 0.8

0.0

0.62

M

20.6 ± 0.8

20.5 ± 0.7

20.5 ± 0.7

0.0

20.0 ± 0.6

20.1 ± 0.6

20.3 ± 0.6c

+1.6

< 0.01

HDL particles

Large HDL particles

F

7.4 ± 3.7

7.8 ± 3.5

7.4 ± 3.8

-0.3

5.8 ± 4.1

5.1 ± 2.6c

5.7 ± 3.1

-2.6

0.83

M

5.4 ± 3.0

5.7 ± 2.8

5.6 ± 2.9

+3.3

3.5 ± 2.1

3.7 ± 1.4

4.7 ± 2.7c

+34.9

0.03

HDL size

F

9.0 ± 0.4

9.0 ± 0.4

8.9 ± 0.4

-0.7

8.8 ± 0.3

8.7 ± 0.2

8.8 ± 0.3

+0.4

0.07

M

8.7 ± 0.4

8.8 ± 0.4

8.7 ± 0.4

0.0

8.5 ± 0.2

8.6 ± 0.2c

8.6 ± 0.4c

+1.6

0.03

Lipid profiles

HDL-cholesterol

F

55.9 ± 12.6

57.2 ± 11.8

52.9 ± 13.0

-5.3

49.2 ± 15.5

40.7 ± 10.5b

45.5 ± 9.3c

-7.4

0.77

M

45.9 ± 13.0

47.3 ± 11.7

43.8 ± 12.6

-4.5

38.9 ± 8.1

34.8 ± 6.6c

40.4 ± 10.6

+3.8

0.03

Tot cholesterol

F

211 ± 35

213 ± 44

208 ± 43

-1.4

206 ± 48

181 ± 42b

197 ± 43

-4.5

0.42

M

173 ± 40

173 ± 38

177 ± 44

+2.0

182 ± 45

156 ± 43b

171 ± 41

-6.4

0.02

Triglycerides

F

164 ± 105

181 ± 193

157 ± 85

-3.9

192 ± 100

188 ± 83

199 ± 117

+3.9

0.54

M

134 ± 95

139 ± 62

148 ± 94

+9.8

187 ± 100

149 ± 59c

140 ± 65c

-24.9

< 0.01


Values are presented as mean ± SD; differences between table values and calculated values are due to rounding; % change = week 0–52. There were 34 women and 39 men in each group, there was no missing data. a: p values resulting from independent samples t-tests (two-tailed) of Baseline to Week 52 changes for female Ornish participants compared to female controls and male Ornish participants compared to male controls, b: values at Week 12 and Week 52 were significantly different from Baseline at p < 0.001 based on repeated measures ANOVA (time point was the within-subjects factor, cohort type and gender within cohorts were the between-subjects factors) using a Bonferroni adjustment for multiple comparisons by time point, group, and gender within group, c: values at Week 12 and Week 52 were significantly different from Baseline at p < 0.05 based on repeated measures ANOVA (time point was the within-subjects factor, cohort type and gender within cohorts were the between-subjects factors) using a Bonferroni adjustment for multiple comparisons by time point, group, and gender within group.

Decewicz et al. Lipids in Health and Disease 2009 8:26   doi:10.1186/1476-511X-8-26

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