Figure 1.

Metabolism of essential fatty acids. Prostaglandins of 3 series are less pro-inflammatory compared to prostaglandins of 2 series. Resolvins are formed from both EPA and DHA and are known to have anti-inflammatory actions and participate in the resolution of inflammation. EPA can be converted to DHA. DHA can be retroconverted to EPA. It is estimated that about 30–40% of DHA can be retroconverted to EPA. The biochemical and/or clinical significance of this retroconversion of DHA to EPA are not known. ____ Indicates beneficial action in the form of increase in the synthesis, action, or remission of disease process. ____ Indicates decrease in the synthesis, action or enhancement of pathological process. ____ Indicates inhibition of HMG-CoA and ACE enzymes by PUFAs/EFAs.