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Plasma lipids in wild-type and apolipoprotein E knockout mice fed low and high fat diets |
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| Diet |
Gene |
Cholesterol (mM) mean ± S.E.M |
Triglyceride (mM) mean ± S.E.M |
|
|
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| LF |
WT |
2.1 ± 0.05 |
0.69 ± 0.19 |
| LF |
Apo E KO |
*6.95 ± 1.97 |
0.68 ± 0.09 |
| HF |
WT |
2.2 ± 0.46 |
0.42 ± 0.12 |
| HF |
Apo E KO |
*14.3 ± 0.01 |
0.38 ± 0.12 |
|
*P < 0.05 S.E.M = standard error of the mean Table shows plasma cholesterol and triglyceride concentrations (mean ± SEM, n = 6 mice per group) in C57BL/6J WT mice and apo E KO mice maintained on either LF or HF diet for six-months. Apo E KO mice had significantly elevated levels of plasma cholesterol compared to WT controls under both feeding regimens (P < 0.05). High-fat feeding further exacerbated the elevation of cholesterol in apo E KO mice compared to HF-WT (P < 0.001) and LF-APOE KO mice (P < 0.05). Plasma triglyceride was not significantly different between groups. | |||
Galloway et al. Lipids in Health and Disease 2008 7:15 doi:10.1186/1476-511X-7-15 |
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