Table 3 |
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|
Effects of the chamiloflan on the ceramide content in the liver of the normal and CCl4-treated rats. |
||
| Animals |
Ceramide |
Ceramide/SM |
|
|
||
| Un-treated |
6.74 ± 0.54 |
0.131 ± 0.010 |
| Control (1) |
6.95 ± 0.45 |
0.121 ± 0.015 |
| Chamiloflan-treated |
6.83 ± 0.23 |
0.112 ± 0.005 |
| Control (2) |
5.67 ± 0.46 |
0.117 ± 0.010 |
| CCl4-treated |
7.34 ± 0.47 * |
0.162 ± 0.013 * |
| Chamiloflan + CCl4-treated |
5.93 ± 0.51 |
0.135 ± 0.017 |
|
The rats were fed by the chamiloflan (160 mg/kg body weight) or ethanol (1 %, 5 ml/kg body weight) (control 1 group) intragastrically daily for 6 days. The CCl4 (50 % in corn oil, 4 ml/kg body weight) was injected subcutaneously daily for 4 days. Some of the CCl4- treated rats were fed by the chamiloflan (160 mg/kg body weight) daily for 6 days intragastrically. Control (2) rats were injected subcutaneously by the corn oil (2 ml/kg body weight) daily for 4 days and fed by the ethanol (1 %, 5 ml/kg body weight) daily for 6 days. The animals were starved overnight prior the experiments. The amount of the ceramides in the liver homogenate was represented as nmol per mg of protein. Results are mean ± SE of 10 experiments performed in duplicate. * R < 0.05, CCl4-treated rats vs. control. | ||
Babenko and Shakhova Lipids in Health and Disease 2008 7:1 doi:10.1186/1476-511X-7-1 |
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