Table 2

Table 2
List of genes identified by literature mining that modulate homocysteine levels
S.No	Symbol	Gene Name	Function

1.	Mthfr	Methylenetetrahydrofolate Reductase	Conversion of 5, 10-methylene-tetrahydrofolate to 5-methyl-tetrahydrofolate.
2.	Cbs	Cystathionine beta-synthase	Condensation of homo-cysteine and serine to form cystathionine
3.	Mtr	Methyltetrahydrofolatehomocysteine methyltransferase	Remethylation of homocysteine to methionine
4.	Mtrr	Methionine synthase reductase	Reductive regeneration of cob(I)alamin cofactor required for the maintenance of MTR in a functional state
5.	Rfc-1	Reduced-folate carrier	5-methyl-tetrahydrofolate internalization in cell
6	Gcp II/Folh1	Glutamate Carboxypeptidase II	Polyglutamate converted to monoglutamate folate by action of the enzyme folylpoly gammaglutamate carboxy-peptidase (FGCPI), an enzyme expressed by GCPII.
7	eNos	Endothelial Nitric oxide synthase	Conversion of L-Arginine to L-Citrulline and nitric oxide synthase (NO)
8.	Tc II	Transcobalamine II	Transport of vitamin B12
9.	Shmt1	Serine Hydroxymethyltransferase 1	Reversible conversion of serine and tetrahydrofolate to glycine and 5, 10-methylene tetrahydrofolate.
10.	Tyms	Thymidylate Synthase	5, 10-methylene THF and deoxyuridylate to form dihydro-folate and thymidylate.
11	Cth	Cystathionine Gamma-Lyase	Hydrolysis of cystathionine to cysteine and α-Ketoglutarate
12	Mthfd	Methylene-tetra hydrofolate dehydrogenase	Conversion of 5, 10-methylene-tetrahydrofolate to5, 10methenyl-tetrahydrofolate.
13	Mthfs	Methenyltetrahydrofolate synthetase	Conversion of 5-formyltetrahydrofolate to 5, 10-methenyltetrahydrofolate.
14	Apo E	Apolipoproteine E	Mediates the binding, internalization, and catabolism of lipoprotein particles.
15	Vegf	Vascular endothelial growth factor	Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth.
16	Pon1	Paraoxonase 1	Hydrolyzes the toxic organo-phosphorus. It also mediate an enzymatic protection of LDL against oxidative modification.
17	Bhmt	Betaine-homocysteine methyltransferase	In Liver & kidney it catalyses the conversion of betaine to dimethyl glycine (DMG).
18	Mat1A	Methionine Adenosyltransferase 1A	Methionine to SAM by transfer of the adenosyl moiety of ATP to the sulfur atom of methionine
19	Ahcy	S-adenosylhomocysteine hydrolase	Hydrolysis of AdoHcy to adenosine and homocysteine
20	Cbl	Cystathionine beta lyase	Conversion of cystathionine to homocysteine.
22	Factor V	Coagulation factor V	Cofactor for the factor Xa-catalyzed activation of prothrombin to the clotting enzyme thrombin.
23	Pai-1	Prothrombin activator inhibitor-1	Inhibition of fibrinolysis by inhibiting the plasminogen-activator and t-PA.

Sharma et al. Lipids in Health and Disease 2006 5:1 doi:10.1186/1476-511X-5-1