Figure 1.

Effect of histidine on ATX-stimulated motility. The modified Boyden chamber motility assays are described in Materials and Methods. L-Histidine inhibits the motility response of A2058 and SKOV-3 cells to ATX but not to LPA (concentrations shown). All data are shown as Mean ± SEM. Means were analyzed utilizing the ANOVA/Tukey's post-test (GraphPad Prism, San Diego, CA): * (p < 0.001) for histidine-treated vs. untreated controls.