Table 7

Fecal bile acids and neutral sterols in minipigs treated with G. lucidum and lovastatin (nmol/g dry feces)

Bile acids
 Neutral Sterols
Group
 NCT
 C
 CDC
 COP-ol
 COP-3-one
 CHOL erol
 CHOL anol
All pigs (D1)
 1.98
 0.86
 0.66a
 2.41a
 0.10a
 1.73a*
 0.96
All pigs (D14)
 1.98
 1.33
 0.16
 3.75
 0.17
 2.96
 0.91
Gl (D14)
 1.98
 1.61
 0.14
 3.61
 0.18
 3.37
 0.87b*
Gl (D29)
 1.98
 0.81
 0.16
 4.44
 0.15
 3.15
 1.22
Lovastatin (D14)
 1.98
 0.99
 0.19
 3.92
 0.15
 2.44
 0.96
Lovastatin (D29)
 1.98
 1.23
 0.18
 3.28
 0.16
 2.34
 1.14

Feces were collected on D1, 14 and 29. A quantitative fecal collection was not possible, hence results are expressed per gram of feces. Abbreviations: refer to Table 4, except, NCT, 23- Nor β cholanate 5α,7α,12α triol. A paired, 2-tailed students t-test, equal variances, evaluated effects of the high cholesterol and fat diet, between D1-14 (10 minipigs); and the effects of Gl or lovastatin between D15-29 (5 minipigs/group), indicated as follows: aD1 vs 14, for all minipigs combined (P < 0.001).bD14 vs 29 (P < 0.05). *0.05 < P < 0.1, to indicate statistical trends.

Berger et al. Lipids in Health and Disease 2004 3:2   doi:10.1186/1476-511X-3-2