Table 7

Fecal bile acids and neutral sterols in minipigs treated with G. lucidum and lovastatin (nmol/g dry feces)

Bile acids

Neutral Sterols


Group

NCT

C

CDC

COP-ol

COP-3-one

CHOL erol

CHOL anol


All pigs (D1)

1.98

0.86

0.66a

2.41a

0.10a

1.73a*

0.96

All pigs (D14)

1.98

1.33

0.16

3.75

0.17

2.96

0.91

Gl (D14)

1.98

1.61

0.14

3.61

0.18

3.37

0.87b*

Gl (D29)

1.98

0.81

0.16

4.44

0.15

3.15

1.22

Lovastatin (D14)

1.98

0.99

0.19

3.92

0.15

2.44

0.96

Lovastatin (D29)

1.98

1.23

0.18

3.28

0.16

2.34

1.14


Feces were collected on D1, 14 and 29. A quantitative fecal collection was not possible, hence results are expressed per gram of feces. Abbreviations: refer to Table 4, except, NCT, 23- Nor β cholanate 5α,7α,12α triol. A paired, 2-tailed students t-test, equal variances, evaluated effects of the high cholesterol and fat diet, between D1-14 (10 minipigs); and the effects of Gl or lovastatin between D15-29 (5 minipigs/group), indicated as follows: aD1 vs 14, for all minipigs combined (P < 0.001).bD14 vs 29 (P < 0.05). *0.05 < P < 0.1, to indicate statistical trends.

Berger et al. Lipids in Health and Disease 2004 3:2   doi:10.1186/1476-511X-3-2

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