Table 6

Plasma cholesterol and triacylglycerol in minipigs treated with G. lucidum and lovastatin (mmol/L)

Group

TC

TC

TC

TC

TAG

TAG

TAG

TAG

VLDL

VLDL

LDL

LDL

HDL

HDL

LDL/HDL

LDL/HDL

D1

D14

D21

D29

D1

D14

D21

D29

D14

D29

D14

D29

D14

D29

D14

D29


Gl (2.5%)

2.47a

3.21bc

2.81

2.58

0.53

0.57

0.80

0.69

0.07

0.09

1.45c

1.08

1.69c

1.42

0.88

0.79

Lovastatin

2.36a

3.00

2.44

2.81

0.50

0.60

0.59

0.71

0.10

0.09

1.40

1.29

1.50

1.43

0.95

0.91


Lovastatin was administered at 80 mg/d. Between D1-14, all pigs received a high cholesterol and fat control diet; from D15-29, pigs received either G. lucidum (Gl) extract or lovastatin. The same statistical conclusions were reached if all 10 pigs were compared between D1-14. Pigs were randomly selected to receive either GI or lovastatin before study commencement. Student's, paired, 1-tailed, t-test, was utilized for statistical comparisons. Statistically significant changes (P < 0.05, 1-tailed testing) in cholesterol parameters are indicated as follows: aD1 vs. 14; bD14 vs. 21; cD14 vs. 29. Abbreviations: refer to Table 3. There was a slight trend for 2.5% Gl to reduce LDL/HDL ratio between D14-29 (P < 0.11, 1-tailed testing).

Berger et al. Lipids in Health and Disease 2004 3:2   doi:10.1186/1476-511X-3-2

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