Table 6

Plasma cholesterol and triacylglycerol in minipigs treated with G. lucidum and lovastatin (mmol/L)
Group
 TC
 TC
 TC
 TC
 TAG
 TAG
 TAG
 TAG
 VLDL
 VLDL
 LDL
 LDL
 HDL
 HDL
 LDL/HDL
 LDL/HDL

D1
 D14
 D21
 D29
 D1
 D14
 D21
 D29
 D14
 D29
 D14
 D29
 D14
 D29
 D14
 D29
Gl (2.5%)
 2.47a
 3.21bc
 2.81
 2.58
 0.53
 0.57
 0.80
 0.69
 0.07
 0.09
 1.45c
 1.08
 1.69c
 1.42
 0.88
 0.79
Lovastatin
 2.36a
 3.00
 2.44
 2.81
 0.50
 0.60
 0.59
 0.71
 0.10
 0.09
 1.40
 1.29
 1.50
 1.43
 0.95
 0.91

Lovastatin was administered at 80 mg/d. Between D1-14, all pigs received a high cholesterol and fat control diet; from D15-29, pigs received either G. lucidum (Gl) extract or lovastatin. The same statistical conclusions were reached if all 10 pigs were compared between D1-14. Pigs were randomly selected to receive either GI or lovastatin before study commencement. Student's, paired, 1-tailed, t-test, was utilized for statistical comparisons. Statistically significant changes (P < 0.05, 1-tailed testing) in cholesterol parameters are indicated as follows: aD1 vs. 14; bD14 vs. 21; cD14 vs. 29. Abbreviations: refer to Table 3. There was a slight trend for 2.5% Gl to reduce LDL/HDL ratio between D14-29 (P < 0.11, 1-tailed testing).

Berger et al. Lipids in Health and Disease 2004 3:2   doi:10.1186/1476-511X-3-2