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Open Access Research

The LRP6 rs2302685 polymorphism is associated with increased risk of myocardial infarction

Shun Xu123, Jie Cheng123, Yu-ning Chen123, Keshen Li4, Ze-wei Ma12, Jin-ming Cen5, Xinguang Liu123, Xi-li Yang5, Can Chen6 and Xing-dong Xiong123*

Author Affiliations

1 Institute of Aging Research, Guangdong Medical College, Dongguan, P.R. China

2 Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan, P.R. China

3 Institute of Biochemistry & Molecular Biology, Guangdong Medical College, Zhanjiang, P.R. China

4 Key Laboratory of Neurodegenerative Disease and Aging Research, Affiliated Hospital of Guangdong Medical College, Zhanjiang, P.R. China

5 Department of Cardiovascular Disease, The First People’s Hospital of Foshan, Foshan, P.R. China

6 Department of Cardiovascular Disease, The Affiliated Hospital of Guangdong Medical College, Zhanjiang, P.R. China

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Lipids in Health and Disease 2014, 13:94  doi:10.1186/1476-511X-13-94

Published: 7 June 2014

Abstract

Background

Abnormal lipids is one of the critical risk factors for myocardial infarction (MI), however the role of genetic variants in lipid metabolism-related genes on MI pathogenesis still requires further investigation. We herein genotyped three SNPs (LRP6 rs2302685, LDLRAP1 rs6687605, SOAT1 rs13306731) in lipid metabolism-related genes, aimed to shed light on the influence of these SNPs on individual susceptibility to MI.

Methods

Genotyping of the three SNPs (rs2302685, rs6687605 and rs13306731) was performed in 285 MI cases and 650 control subjects using polymerase chain reaction–ligation detection reaction (PCR–LDR) method. The association of these SNPs with MI and lipid profiles was performed with SPSS software.

Results

Multivariate logistic regression analysis showed that C allele (OR = 1.62, P = 0.039) and the combined CT/CC genotype (OR = 1.67, P = 0.035) of LRP6 rs2302685 were associated with increased MI risk, while the other two SNPs had no significant effect. Further stratified analysis uncovered a more evident association with MI risk among younger subjects (≤60 years old). Fascinatingly, CT/CC genotype of rs2302685 conferred increased LDL-C levels compared to TT genotype (3.0 mmol/L vs 2.72 mmol/L) in younger subjects.

Conclusions

Our data provides the first evidence that LRP6 rs2302685 polymorphism is associated with an increased risk of MI in Chinese subjects, and the association is more evident among younger individuals, which probably due to the elevated LDL-C levels.

Keywords:
LRP6; Single nucleotide polymorphism; Myocardial infarction; Risk