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Open Access Research

The associations between endothelial lipase 584C/T polymorphism and HDL-C level and coronary heart disease susceptibility: a meta-analysis

Gaojun Cai1*, Zhiying Huang2, Bifeng Zhang3, Weijin Weng1 and Ganwei Shi1

  • * Corresponding author: Gaojun Cai cgj982@126.com

  • † Equal contributors

Author Affiliations

1 Department of Cardiology, Wujin Hospital Affiliated to Jiangsu University, Changzhou, Jiangsu Province, China

2 Department of Pediatrics, NO.2 Hospital of Changzhou, Changzhou, Jiangsu, China

3 Department of Medicine, University of Chicago, Chicago, Illinois, USA

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Lipids in Health and Disease 2014, 13:85  doi:10.1186/1476-511X-13-85

Published: 22 May 2014

Abstract

Background

Studies had investigated the relationships between endothelial lipase (EL) 584C/T polymorphism and high density lipoprotein cholesterol (HDL-C) level and coronary heart disease (CHD), but the results were controversial. To investigate a more authentic associations between EL 584C/T polymorphism and HDL-C level, and the risk of CHD, we performed this meta-analysis.

Methods

We searched electric databases for all articles on the associations between EL 584C/T polymorphism and HDL-C level, and CHD risk. Odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the strength of the association between the EL 584C/T polymorphism and the CHD susceptibility. The pooled standardized mean difference (SMD) with 95% CI was used for the meta-analysis of EL 584C/T polymorphism and HDL-C level. Begg’s funnel plots and Egger’s test were used to examine the publication bias.

Results

For CHD association, the pooled OR was 0.829 (95% CI: 0.701-0.980, P = 0.028) for the dominant model and 0.882 (95% CI: 0.779-0.999, P = 0.049) for the allelic model. By meta-regression analysis, we found that only total sample size could influence the initial heterogeneity. When the subgroup analysis was carried out, we found that the protective effect only existed in the subgroups of relatively small sample size. Sensitivity analyses indicated that Tang’s study influenced the overall results significantly. We calculated the pooled ORs again after excluding Tang’s study and found the association between EL 584C/T polymorphism and the risk of CHD was not significant for any genetic model. For HDL-C level association, the carriers of 584 T allele had a higher HDL-C level than the non-carriers. The pooled SMD was 0.399 (95% CI: 0.094-0.704, P = 0.010). When the studies were stratified by ethnicity and total sample size, the positive effects existed in the Caucasians and in subgroups of larger sample size. No significant publication bias was found in the present meta-analysis.

Conclusions

The results of the present meta-analysis suggest that the carriers of EL 584 T allele have a higher HDL-C level in Caucasian populations. Whereas, it might not be a protective factor for CHD.

Keywords:
Endothelial lipase; High density lipoprotein cholesterol; Polymorphism; Coronary heart disease; Meta-analysis