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Open Access Research

CYP4F2 genetic polymorphisms are associated with coronary heart disease in a Chinese population

Changqing Yu12, Qingkai Yan12, Chunjiang Fu12, Weibin Shi12, Hongyong Wang12, Chunyu Zeng12 and Xukai Wang12*

Author Affiliations

1 Department of Cardiology, Daping Hospital, The Third Military Medical University, 10#Changjiangzhilu, Yuzhong District, Chongqing 400042, People’s Republic of China

2 Chongqing Institute of Cardiology, 10#Changjiangzhilu, Yuzhong District, Chongqing 400042, People’s Republic of China

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Lipids in Health and Disease 2014, 13:83  doi:10.1186/1476-511X-13-83

Published: 20 May 2014

Abstract

Background

To explore the relationship between CYP4F2 gene polymorphism and coronary heart disease (CHD) in a Chinese Han population.

Methods

We selected 440 CHD patients and 440 control subjects to perform a case - control study. Four SNPs (rs2108622, rs3093100, rs3093105 and rs3093135) in CYP4F2 gene were genotyped using polymerase chain reaction - restriction fragment length polymorphism (PCR - RFLP) methods. The genotype and haplotype distributions were compared between the case and the control group.

Results

We found both rs2108622 and rs3093105 in CYP4F2 gene were associated with the risk for CHD (P <0.01). Haplotype analysis indicated that GGGT haplotype consisted by rs2108622-rs3093100-rs3093105-rs3093135 was associated with CHD risk (OR = 4.367, 95% CI: 2.241 ~ 8.510; P < 0.001), but GGTA haplotype was associated with decreased risk for CHD (OR = 0.450, 95% CI: 0.111 ~ 0.777; P <0.001).

Conclusion

CYP4F2 gene polymorphisms were associated with the risk of CHD in Chinese population.

Keywords:
Coronary heart disease; CYP4F2 gene; Single nucleotide polymorphism