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Open Access Research

Association of LOX-1 gene polymorphisms with cerebral infarction in northern Chinese Han population

Xu Liu, Rui-Xia Zhu, Lei Li and Zhi-Yi He*

Author Affiliations

Department of Neurology, First Affiliated Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang 110001, Liaoning Province, China

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Lipids in Health and Disease 2014, 13:55  doi:10.1186/1476-511X-13-55

Published: 25 March 2014

Abstract

Background

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays an important role in the pathophysiology of atherosclerosis and thrombosis. This study is aimed at evaluating the potential association of 3’-UTR-C188T and G501C in LOX-1 gene with cerebral infarction.

Methods

A total of 386 patients with cerebral infarction and 386 healthy controls were included in the study, which were unrelated Chinese Han population in the Liaoning Province of northern China. The single nucleotide polymorphisms, 3’-UTR-C188T and G501C, were analyzed by polymerase chain reaction–ligation detection reaction method.

Results

The frequencies of CC + GC genotype, GC genotype and C allele of G501C in the patients with cerebral infarction were significantly higher than those in the controls (P < 0.01, P < 0.01, P = 0.04, respectively). The correlation still remained after adjusting for confounding risk factors of cerebral infarction. In addition, no significant association was observed between 3’-UTR-C188T and cerebral infarction.

Conclusions

The study indicated that the G501C variant in LOX-1 gene may be associated with susceptibility to cerebral infarction, independent of other common risk factors, in northern Chinese Han population.

Keywords:
LOX-1; Ox-LDL; Polymorphisms; Cerebral infarction; Atherosclerosis