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Open Access Research

Apolipoprotein E gene polymorphism and the risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies

Rongjun Zhang, Xiaofeng Wang*, Zongchun Tang, Jianxin Liu, Shuzhen Yang, Youbing Zhang, Yijun Wei, Wenyin Luo, Jun Wang, Jialong Li, Bobo Chen and Kunhu Zhang

Author Affiliations

Department of Neurosurgery, Third Hospital of Chinese PLA, 45 Dongfeng Road, Jin Tai District, Baoji 721004, Shanxi Province, China

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Lipids in Health and Disease 2014, 13:47  doi:10.1186/1476-511X-13-47

Published: 12 March 2014



Studies investigating the association between the apolipoprotein E (APOE) gene polymorphism and the risk of intracerebral hemorrhage (ICH) have reported conflicting results. We here performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship.


Published literature from the National Library of Medline and Embase databases were retrieved. Odds ratio (OR) and 95% confidence interval (CI) were calculated in fixed- or random-effects models when appropriate. Subgroup analyses were performed by race.


This meta-analysis included 11 case–control studies, which included 1,238 ICH cases and 3,575 controls. The combined results based on all studies showed that ICH cases had a significantly higher frequency of APOE ϵ4 allele (OR= 1.42, 95% CI= 1.21,1.67, P<0.001). In the subgroup analysis by race, we also found that ICH cases had a significantly higher frequency of APOE ϵ4 allele in Asians (OR= 1.52, 95% CI= 1.20,1.93, P<0.001) and in Caucasians (OR= 1.34, 95% CI= 1.07,1.66, P=0.009). There was no significant relationship between APOE ϵ2 allele and the risk of ICH.


Our meta-analysis suggested that APOE ϵ4 allele was associated with a higher risk of ICH.

Apolipoprotein E; Intracerebral hemorrhage; Gene polymorphism; Meta-analysis