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Open Access Research

Association of apolipoprotein E polymorphism with maximal oxygen uptake after exercise training: a study of Chinese young adult

Bo Yu12, Wenhua Chen2*, Renwei Wang1, Qi Qi2, Kunpeng Li2, Wen Zhang2 and Huiru Wang3

Author Affiliations

1 School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China

2 Department of Rehabilitation Medicine, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China

3 Department of Physical Education, Shanghai Jiao Tong University, Shanghai 200240, China

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Lipids in Health and Disease 2014, 13:40  doi:10.1186/1476-511X-13-40

Published: 27 February 2014

Abstract

Background

Although a few studies have been conducted, it is still unclear whether the apolipoprotein E (APOE) polymorphism is associated with maximal oxygen uptake (VO2max) after exercise training. The objective of this study was to examine if the APOE gene polymorphisms affect VO2max after exercise training in Chinese young adult.

Methods

A total of 360 Chinese young adult (180 male and 180 female) were recruited into this gender-specific cohorts. Anthropometrics, serum lipids, and VO2max were measured pre and post 6 months of supervised exercise training. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess the APOE gene polymorphisms.

Results

VO2max after exercise training increased significantly higher in carriers of E2/E3 in male [odds ratio (OR) =0.68, 95% confidence interval (CI) = 0.04, 1.32; P = 0.04] and female (OR =0.62, 95% CI = 0.05, 1.18; P = 0.03). VO2max after exercise training increased significantly higher in carriers of E3/E4 in male (OR =0.60, 95% CI = 0.09, 1.11; P = 0.02) and female (OR =0.62, 95% CI = 0.09, 1.15; P = 0.02). No significant differences were found in carriers of E2/E2, E2/E4, E3/E3, E4/E4 in either male nor female.

Conclusion

Our study found that APOE gene polymorphism was associated with VO2max levels after exercise training in Chinese young adult. In the future, further experiments will be necessary to confirm this finding and to find the possible mechanism.

Keywords:
Apolipoprotein E; Gene polymorphism; Maximal oxygen uptake; Exercise training