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Open Access Research

Association of liver X receptor α (LXRα) gene polymorphism and coronary heart disease, serum lipids and glucose levels

Yun-Fei Zhou1, Jing Zhang2, Zong-Xue Li1, Jing-Li Miao1, Qiao-Xiang Yin1, Jun-JIE Li1, Xiao-Yan Zhang1, Yuan-Yuan Li1 and Hui-Lan Luo1*

Author Affiliations

1 The cadre ward of General Hospital of the Air Force PLA, No. 30, Fucheng Road, Haidian District, Beijing 100142, China

2 Combination of traditional Chinese and Western Medicine Hospital of Southern Medical University, Guangzhou 510515, China

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Lipids in Health and Disease 2014, 13:34  doi:10.1186/1476-511X-13-34

Published: 17 February 2014

Abstract

Background

To explore the relationship between the liver X receptor α gene (LXRα) rsl2221497 polymorphism and the susceptibility of coronary heart disease (CHD) and serum lipids and glucose levels.

Methods

The single fluorescently labeled probes technique was used to detect the genotype of rsl2221497 in LXRα gene in 240 CHD patients and 250 healthy control subjects. The difference of genotype distribution between the two groups was analyzed using of Chi-square test. The serum lipids and glucose levels between the different genotypes were also compared.

Results

The risk of CHD in carriers with (AA + GA) genotype was 1.76 times as that in the GG genotype carriers (OR = 1.76, 95% CI: 1.18-2.87, P <0.05), and the risk of CHD in carriers with A allele increased 0.88 times compared to that in G allele carriers (OR = 1.88, 95% CI:1.21-3.43, P <0.01). Logistic regression analysis showed that after adjusting for other confounding factors, A allele was an independent risk for CHD. However, there were no differences in serum lipids and glucose levels between each genotype.

Conclusions

The rsl2221497 polymorphism in LXRα gene was associated with susceptibility of CHD in Han population.

Keywords:
Liver X receptor α; Gene; Coronary heart disease; Polymorphism