Association of liver X receptor alpha (LXRalpha) gene polymorphism and coronary heart disease, serum lipids and glucose levels
Lipids in Health and Disease 2014, 13:34 doi:10.1186/1476-511X-13-34Published: 17 February 2014
To explore the relationship between the liver X receptor alpha gene (LXRalpha) rsl2221497 polymorphism and the susceptibility of coronary heart disease (CHD) and serum lipids and glucose levels.
The single fluorescently labeled probes technique was used to detect the genotype of rsl2221497 in LXRalpha gene in 240 CHD patients and 250 healthy control subjects. The difference of genotype distribution between the two groups was analyzed using of Chi-square test. The serum lipids and glucose levels between the different genotypes were also compared.
The risk of CHD in carriers with (AA + GA) genotype was 1.76 times as that in the GG genotype carriers (OR = 1.76, 95%CI: 1.18-2.87, P <0.05), and the risk of CHD in carriers with A allele increased 0.88 times compared to that in G allele carriers (OR = 1.88, 95% CI:1.21-3.43, P <0.01). Logistic regression analysis showed that after adjusting for other confounding factors, A allele was an independent risk for CHD. However, there were no differences in serum lipids and glucose levels between each genotype.
The rsl2221497 polymorphism in LXRalpha gene was associated with susceptibility of CHD in Han population.