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Open Access Research

PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population

Shu-Jun Gu12, Zhi-Rong Guo2*, Zheng-Yuan Zhou1, Xiao-Shu Hu3 and Ming Wu4

Author Affiliations

1 Center for Disease Control of Changshu, Suzhou, 215500, Jiangsu, China

2 Department of Epidemiology, School of Public Health, Soochow University, Suzhou, Jiangsu 215123, China

3 Health Bureau of Jiangsu Province, Nanjing, Jiangsu 21009, China

4 Center for Disease Control of Jiangsu Province, Nanjing, Jiangsu 210009, China

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Lipids in Health and Disease 2014, 13:23  doi:10.1186/1476-511X-13-23

Published: 26 January 2014

Abstract

Background

The PPAR α and PPAR γ are the key messengers responsible for the translation of nutritional stimuli into changes for the expression of genes, particularly genes involved in lipid metabolism. However, the associations between PPAR α / γ polymorphisms and lipid serum levels in the general population were rarely studied, and the conclusions were conflicting. The objective was to investigate the associations of the PPAR α and PPAR γ polymorphisms with dyslipidemia.

Methods

820 subjects were randomly selected from the Prevention of Multiple Metabolic Disorders and MS in Jiangsu Province cohort populations. The logistic regression model was used to examine the association between these polymorphisms and dyslipidemia. SNPstats was used to explore the haplotype association analyses.

Results

In the codominant and log-additive models, rs1800206, rs1805192 and rs3856806 were all associated with dyslipidemia (P < 0.005). When the most common haplotype L-G (established by rs1800206, rs4253778) was treated as the reference group, the V-G haplotype was associated with dyslipidemia (P < 0.001), higher TC and TG levels (P < 0.01). Moreover, when compared to Pro-C haplotype (established by rs1805192, rs3856806), the Pro-T, Ala-C, Ala-T haplotypes were associated with dyslipidemia (p < 0.001). A-T haplotype was associated with higher TC levels, (p < 0.01), and the P-T, A-C, A-T haplotypes were associated with higher TG levels (p < 0.01).

Conclusions

PPAR α and PPAR γ polymorphisms and haplotypes may be the genetic risk factors for dyslipidemia.

Keywords:
PPAR; Polymorphism; Dyslipidemia; Haplotype