Relationship between CYP7A1 -204A > C polymorphism with gallbladder stone disease and serum lipid levels: a meta-analysis
- Equal contributors
1 Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, 200025 Shanghai, China
2 Department of Emergency, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, 200025 Shanghai, China
Lipids in Health and Disease 2014, 13:126 doi:10.1186/1476-511X-13-126Published: 8 August 2014
The CYP7A1 gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were inconsistent. This meta-analysis aimed to evaluate the influence of the -204A > C polymorphism in the promoter of CYP7A1 gene on the GSD and serum lipid levels.
According to inclusion/exclusion criteria, eligible studies on CYP7A1 gene -204A > C polymorphism of serum lipid levels and the risk of GSD were retrieved. Depending on the between-study heterogeneity, the fixed- or random-effects model was applied, and the data were analyzed using the RevMan software (V5.2).
Five studies totaling 830 GSD patients and 882 healthy controls were used to evaluate the relation of CYP7A1 -204A > C polymorphism with GSD. Overall comparison of alleles A with C in all study population yielded 5% but non-significant increased risk of GSD (OR = 1.05, 95% CI: 0.91 − 1.22, P = 0.48). Subgroup analysis by ethnic differences did not show any association between CYP7A1 -204A > C polymorphism and GSD either. Four studies totaling 802 cases and 691 controls were used to assess the relation of CYP7A1 -204A > C polymorphism with serum lipid levels. All the subjects were from the Asian population. The pooled effects indicated that AC genotype had higher levels of TG than AA (MD = -0.42, 95% CI: -0.76 − -0.08, P = 0.01). CC genotype in cases had higher levels of TC (MD = 0.65, 95% CI: 0.25 − 1.05, P = 0.001) and LDL-C (MD = 0.40, 95% CI: 0.06 − 0.73, P = 0.02) than AA, AA (MD = -0.35, 95% CI: -0.60 − -0.10, P = 0.007) and AC (MD = −0.35, 95% CI: -0.61 − -0.08, P = 0.01) genotypes in controls had higher levels of TC than CC, and AA genotype in controls had higher levels of HDL-C than CC (MD = -0.15, 95% CI: -0.21 − -0.09, P < 0.00001).
The CYP7A1 -204A > C polymorphism is significantly associated with serum lipid levels in Asian population, but not gallbladder stone disease.