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Open Access Research

Increased Hs-CRP/adiponectin ratio is associated with increase carotid intima-media thickness

Huocheng Liao1, Zhiming Li2, Dongdan Zheng3, Jianping Liu1, Yan Liu1, Chun Xiao1 and Hongguang Wang4*

Author Affiliations

1 Department of Cardiology, the 3rd People’s Hospital, Huizhou, China

2 Department of Cardiology, Huizhou Municipal Central Hospital, 41st Eling North RD, Huicheng District, Huizhou, China

3 Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

4 Internal Medicine-Cardiovascular Department, Dongying People’s Hospital of Shandong Province, NO.137, Nanyi Road, Dongying, Shangdong Province, China

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Lipids in Health and Disease 2014, 13:120  doi:10.1186/1476-511X-13-120

Published: 29 July 2014

Abstract

Background

High sensitivity C-reactive protein (Hs-CRP) and adiponectin (APN) are two critical cytokines and exert inverse effects on atherosclerosis initiation and progression. The purpose of our study was to investigate the value of Hs-CRP and ANP ratio (Hs-CRP/APN ratio) on evaluating atherosclerosis progression.

Method

One hundred sixty consecutive participants underwent carotid intima-media thickness (CIMT) measured by ultrasound were enrolled and drawn fasting blood samples for plasma levels Hs-CRP and APN, serum levels of lipid profiles and fasting blood glucose evaluation. Other anthropometrics and clinical status were collected by questionnaire. All participants were divided into 4 groups according to the baseline Hs-CRP/APN ratio and underwent CIMT measurement every 6 months. CIMT increment and composite cardiovascular endpoints were compared after 24 months’ follow-up.

Results

At baseline, body mass index (BMI), smoking, diabetic mellitus, usage of statins, Hs-CRP and APN independently correlated with Hs-CRP/APN ratio as analyzed by spearman rank correlation. Smoking, serum level of LDL-C, plasma level of Hs-CRP and Hs-CRP/APN ratio were positively correlated with CIMT while usage of statins and plasma level of APN were negatively correlated with CIMT as analyzed by multiple linear regression analysis. After 24 months’ follow-up, the progression of CIMT was the most prominent in the fourth quartile of baseline Hs-CRP/APN ratio. In addition, the incidence of composite cardiovascular endpoint was also higher in the fourth quartile as compared to the other 3 lower quartiles.

Conclusion

Hs-CRP/APN ratio was a useful predictor to discriminate subjects who were at increased risk of atherosclerosis progression.

Keywords:
High sensitivity C-reactive protein; Adiponectin; Atherosclerosis