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Effect of dietary resveratrol on the metabolic profile of nutrients in obese OLETF rats

Koji Nagao1*, Tomoyuki Jinnouchi1, Shunichi Kai1 and Teruyoshi Yanagita12

Author Affiliations

1 Department of Applied Biochemistry and Food Science, Saga University, Saga, 840-8502, Japan

2 Department of Health and Nutrition Sciences, Nishikyushu University, Kanzaki, 842-8585, Japan

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Lipids in Health and Disease 2013, 12:8  doi:10.1186/1476-511X-12-8

Published: 4 February 2013



Resveratrol (trans-3,4,5-trihydroxystilbene) is a naturally occurring phytoalexin produced by plants in response to various stresses. Several studies have shown that resveratrol is present in significant amounts in a variety of human diets, including wines, grapes, berries, and peanuts, and it possesses several beneficial health properties, such as atheroprotective, anti-obesity, anti-cancer, anti-inflammatory and antioxidant activities. In this study, we evaluated the effect of resveratrol on the pathogenesis of obesity and the metabolic profile of nutrients in non-high fat-fed obese OLETF rats.


Although lipid parameters in the serum and liver were not changed, the accumulation of abdominal white adipose tissues was markedly prevented in resveratrol diet-fed OLETF rats after 4 weeks of feeding. The results of the respiratory gas analysis indicated that dietary resveratrol induced the partial enhancement of fat metabolism and sparing actions for carbohydrate and protein at 1 week and 3 weeks of feeding in OLETF rats. Additionally, the adipose mRNA level of carnitine palmitoyltransferase in the resveratrol diet-fed OLETF rats was higher than the control rats after 4 weeks of feeding.


Our study demonstrated that dietary resveratrol can prevent obesity through a change in the metabolic profile of nutrients in obese OLETF rats.

Resveratrol; Respiratory gas analysis; Metabolic profile; Obesity; OLETF rat