If the wheel ain’t broke, don’t reinvent it
Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland
Lipids in Health and Disease 2013, 12:51 doi:10.1186/1476-511X-12-51Published: 11 April 2013
During the past 100 years, several theories explaining human atherosclerosis have been postulated and tested. More than anything else, experimental and observational evidence has supported a very strong causal role for dyslipidemia. This has been established as the current paradigm in both biomedical research as well as public health policies. Recently, a novel hypothesis for the etiology of atherosclerosis was presented. The purpose of this commentary is to critically evaluate its validity.