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Open Access Highly Accessed Open Badges Commentary

If the wheel ain’t broke, don’t reinvent it

Pauli Ohukainen

Author Affiliations

Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland

Lipids in Health and Disease 2013, 12:51  doi:10.1186/1476-511X-12-51

Published: 11 April 2013


During the past 100 years, several theories explaining human atherosclerosis have been postulated and tested. More than anything else, experimental and observational evidence has supported a very strong causal role for dyslipidemia. This has been established as the current paradigm in both biomedical research as well as public health policies. Recently, a novel hypothesis for the etiology of atherosclerosis was presented. The purpose of this commentary is to critically evaluate its validity.

Cholesterol; Mevalonate; Hypothesis