Association study of angiotensin converting enzyme gene polymorphism with elderly diabetic hypertension and lipids levels
1 The cadre ward of General Hospital of the Air Force PLA, No. 30, Fucheng Road, Haidian District, Beijing 100142, China
2 Combination of traditional Chinese and Western Medicine Hospital of Southern Medical University, Guangzhou 510515, China
Lipids in Health and Disease 2013, 12:187 doi:10.1186/1476-511X-12-187Published: 19 December 2013
To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and diabetic essential hypertension in elderly population.
Polymerase chain reaction (PCR) technique was used in 260 elderly normal control patients, 205 elderly hypertensive patients and 138 elderly diabetic hypertensive patients to detect the I/D polymorphism in ACE gene.
DD genotype frequency (0.352) and D allele frequency (0.543) in elderly hypertensive patients were higher than those in the normal control patients. DD genotype (0.421) and D allele frequency (0.579) in elderly diabetic hypertensive patients were significantly higher than those in the control patients (0.133 and 0.250). The differences of DD genotype and D allele frequency between the elderly hypertensive patients and the elderly diabetic hypertensive patients were not significant (P > 0.05).
ACE gene deletion is a risk factor for hypertension but is not a risk factor for diabetes in elderly population.