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Open Access Research

Association study of angiotensin converting enzyme gene polymorphism with elderly diabetic hypertension and lipids levels

Yun-Fei Zhou1, Hui Yan2, Xiao-Ping Hou1, Jing-Li Miao1, Jing Zhang1, Qiao-Xiang Yin1, Jun-Jie Li1, Xiao-Yan Zhang1, Yuan-Yuan Li1 and Hui-Lan Luo1*

Author Affiliations

1 The cadre ward of General Hospital of the Air Force PLA, No. 30, Fucheng Road, Haidian District, Beijing 100142, China

2 Combination of traditional Chinese and Western Medicine Hospital of Southern Medical University, Guangzhou 510515, China

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Lipids in Health and Disease 2013, 12:187  doi:10.1186/1476-511X-12-187

Published: 19 December 2013

Abstract

Objective

To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and diabetic essential hypertension in elderly population.

Methods

Polymerase chain reaction (PCR) technique was used in 260 elderly normal control patients, 205 elderly hypertensive patients and 138 elderly diabetic hypertensive patients to detect the I/D polymorphism in ACE gene.

Results

DD genotype frequency (0.352) and D allele frequency (0.543) in elderly hypertensive patients were higher than those in the normal control patients. DD genotype (0.421) and D allele frequency (0.579) in elderly diabetic hypertensive patients were significantly higher than those in the control patients (0.133 and 0.250). The differences of DD genotype and D allele frequency between the elderly hypertensive patients and the elderly diabetic hypertensive patients were not significant (P > 0.05).

Conclusion

ACE gene deletion is a risk factor for hypertension but is not a risk factor for diabetes in elderly population.

Keywords:
Angiotensin converting enzyme gene; Insertion/deletion polymorphism; Elderly; Hypertension; Diabetic hypertension