SAA1 gene variants and childhood obesity in China
Department of Pediatric, RenMin Hospital of Wuhan University, Jie Fang Road, Wuchang district, Wuhan 430060, China
Lipids in Health and Disease 2013, 12:161 doi:10.1186/1476-511X-12-161Published: 30 October 2013
Obesity increases the risk for insulin resistance and metabolic syndrome in both adults and children. SAA is a member of apolipoprotein and plays an important role in maintaining glucose and lipid homeostasis. The purpose of this study was to assess SAA1 allelic variants with obesity in young school-age children.
A total of 520 consecutive children ages 5–15 years were recruited. Children were divided based on BMI z score into Obese (OB; BMI z score ≥1.65; n = 253) and non-obese (NOB; n = 267). Four SNPs of the human SAA1 gene (rs12218, rs4638289, rs7131332 and rs11603089) were genotyped by use of polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) method.
Compared to NOB, circulating SAA levels were increased in OB, as were LDL-C, TG and TC concentration. Obese children showed increased frequency of rs12218 and rs4638289 polymorphism compared to control children. There were no differences between OB and NOB for the other 2 polymorphisms. Only the rs4638289 polymorphism showed significant contributions to higher SAA plasma levels.
SAA1 genetic polymorphism was associated with obesity in Chinese children.