Impact of APOE gene polymorphisms on the lipid profile in an Algerian population
1 Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de Technologie d’Oran Mohamed Boudiaf, Oran, Algeria
2 Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université d’Oran, Oran, Algeria
3 INSERM, U744; Institut Pasteur de Lille, Université Lille Nord de France, Lille, France
4 Caisse Nationale des Assurances Sociales des travailleurs salariés, Clinique Spécialisée en Orthopédie et Rééducation des Victimes des Accidents de Travail, Oran, Algeria
5 Faculté de Médecine, Université Djillali Liabes de Sidi Bel Abbes, Sidi Bel Abbes, Algeria
6 LABoratoire des Systèmes d’Information en Santé, Université d’Oran, Oran, Algeria
Lipids in Health and Disease 2013, 12:155 doi:10.1186/1476-511X-12-155Published: 25 October 2013
The importance of apolipoprotein E (APOE) in lipid and lipoprotein metabolism is well established. However, the impact of APOE polymorphisms has never been investigated in an Algerian population. This study assessed, for the fist time, the relationships between three APOE polymorphisms (epsilon, rs439401, rs4420638) and plasma lipid concentrations in a general population sample from Algeria.
The association analysis was performed in the ISOR study, a representative sample of the population living in Oran (787 subjects aged between 30 and 64). Polymorphisms were considered both individually and as haplotypes.
In the ISOR sample, APOE ϵ4 allele carriers had higher plasma triglyceride (p=0.0002), total cholesterol (p=0.009) and LDL-cholesterol (p=0.003) levels than ϵ3 allele carriers. No significant associations were detected for the rs4420638 and rs439401 SNPs. Linkage disequilibrium and haplotype analyses confirmed the respectively deleterious and protective impacts of the ϵ4 and ϵ2 alleles on LDL-cholesterol levels and showed that the G allele of the rs4420638 polymorphism may exert a protective effect on LDL-cholesterol levels in subjects bearing the APOE epsilon 4 allele.
Our results showed that (i) the APOE epsilon polymorphism has the expected impact on the plasma lipid profile and (ii) the rs4420638 G allele may counterbalance the deleterious effect of the ϵ4 allele on LDL-cholesterol levels in an Algerian population.