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A high normal TSH level is associated with an atherogenic lipid profile in euthyroid non-smokers with newly diagnosed asymptomatic coronary heart disease

Xing Wanjia1, Wang Chenggang23, Wang Aihong4, Yang Xiaomei1, Zhao Jiajun1, Yu Chunxiao1, Xu Jin1, Hou Yinglong5* and Gao Ling6*

Author Affiliations

1 Department of Endocrinology, Provincial Hospital affiliated to Shandong University, Jinan, People's Republic of China

2 School of Public Health, Shandong University, Jinan, People's Republic of China

3 Department of Preventive Medicine, Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China

4 Department of Cardiology, Provincial Hospital affiliated to Shandong University, Jinan, People's Republic of China

5 Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, People's Republic of China

6 Department of Central Laboratory, Provincial Hospital affiliated to Shandong University, Jinan, People's Republic of China

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Lipids in Health and Disease 2012, 11:44  doi:10.1186/1476-511X-11-44

Published: 27 March 2012

Abstract

Background

Serum lipid profiles may be influenced by thyroid function, but the detailed mechanism remains unclear. Increasing evidence suggests that thyrotropin (TSH) may exert extra-thyroidal effects. The goal of this study was to evaluate the relationship between serum TSH levels and the lipid profiles in euthyroid non-smokers with newly diagnosed asymptomatic coronary heart disease (CHD).

Methods

This was a retrospective study of 406 euthyroid non-smokers (187 males and 219 females) with newly diagnosed asymptomatic CHD from 2004 to 2010 in Jinan, China. Lipid parameters and the levels of TSH, FT3, and FT4 were determined. Multiple linear regression analysis and Logistic regression analysis were used to assess the influence of TSH on the lipid profiles and the risks of dyslipidemia.

Results

The TSH level, even within the normal range, was positively and linearly correlated with total cholesterol (TC), non-high density lipoprotein cholesterol (non-HDL-C) and triglycerides (TG) (Beta = 0.173, 0.181 and 0.103, respectively, P < 0.01 in all). With 1 mIU/L rise of TSH, the levels of TC, TG and non-HDL-C will increase by 1.010, 1.064, and 1.062 mmol/L, respectively. The odds ratio of hypercholesterolemia and hypertriglyceridemia with respect to the serum TSH level was 1.640 (95% CI 1.199-2.243, P = 0.002) and 1.349 (95% CI 1.054-1.726, P = 0.017), respectively.

Conclusions

TSH levels were correlated in a positive linear manner with the TC, non-HDL-C and TG levels in euthyroid non-smokers with newly diagnosed asymptomatic CHD. TSH in the upper limits of the reference range might exert adverse effects on lipid profiles and thus representing as a risk factor for hypercholesterolemia and hypertriglyceridemia in the context of CHD.

Keywords:
TSH; Cholesterol; Triglyceride; Coronary heart disease