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Open Access Highly Accessed Review

Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials

Hao Wang1, Ning Xia2, Yang Yang1 and Dao-Quan Peng1*

Author Affiliations

1 Department of Cardiology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, People's Republic of China

2 Department of Pulmonary, Xiangya Hospital, Central South University, Changsha 410011, Hunan, People's Republic of China

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Lipids in Health and Disease 2012, 11:42  doi:10.1186/1476-511X-11-42

Published: 20 March 2012

Abstract

Observational studies have shown that low serum levels of vitamin D have been associated with an atherogenic lipid profile. However, the intervention studies gave divergent results. We conducted a meta-analysis of randomized controlled trials that evaluated the effects of vitamin D supplementation on blood lipids. A systematic literature search was conducted via MEDLINE, Cochrane library, and EMBASE for randomized controlled clinical trials assessing the effects of vitamin D supplementation on lipids. The mean change in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) from baseline was treated as a continuous variable. In all, 12 clinical trials consisting of 1346 participants were included in the analysis. The pooled estimate of effect for vitamin D supplementation on LDL-C was 3.23 mg/dl (95% confidence interval, 0.55 to 5.90 mg/dl). No statistically significant effects for vitamin D supplementation were observed for TC, HDL-C and TG (differences in means were 1.52 mg/dl (-1.42 to 4.46 mg/dl), -0.14 mg/dl (-0.99 to 0.71 mg/dl) and -1.92 mg/dl (-7.72 to 3.88 mg/dl) respectively). The lipid modulating effects of vitamin D supplementation should be further investigated though large-scale, randomized trials with adequate doses which can effectively elevated the active form of vitamin D in plasma and with proper population which has hyperlipemia as an inclusion criterion.

Keywords:
Vitamin D; lipids; cardiovascular disease; meta-analysis