Open Access Research

Lack of association between four SNPs in the SLC22A3-LPAL2-LPA gene cluster and coronary artery disease in a Chinese Han population: a case control study

Xiaofei Lv1, Yuan Zhang2, Shaoqi Rao3, Fengqiong Liu1, Xiaoyu Zuo4, Dongfang Su1, Min Wang1, Min Xia1, Honghui Guo5, Dan Feng4, Changjiang Hong2, Dan Li1, Wenjun Ma6, Ping Ouyang3, Xinrui Li1, Xiang Feng1, Yan Yang1, Wenhua Ling1 and Jian Qiu2*

Author Affiliations

1 Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University (Northern Campus), 74 Zhongshan Road 2, Guangzhou, 510080, China

2 Department of Cardiology, Guangzhou Region General Hospital, 111 Liuhua Road, Guangzhou, 510070, China

3 Institute of Medical Systems Biology; Department of Medical Statistics and Epidemiology, School of Public Health, Guangdong Medical College, Dongguan, Guangdong, 523808, China

4 Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University (Northern Campus), 74 Zhongshan Road 2, Guangzhou, 510080, China

5 Department of Food Science, Yingdong College of Bioengineering, Shaoguan University, Daxue Road, Shaoguan, 512005, Guangdong Province, China

6 Department of Nutrition, Guangdong Provincial People’s Hospital, 106 Zhongshan Road 2, Guangzhou, 510080, China

For all author emails, please log on.

Lipids in Health and Disease 2012, 11:128  doi:10.1186/1476-511X-11-128

Published: 4 October 2012

Abstract

Background

Lipoprotein (a) (Lp [a]) is known being correlated with coronary artery disease (CAD). The SLC22A3-LPAL2-LPA gene cluster, relating with modulating the level of plasma Lp (a), has recently been reported to be associated with CAD in Caucasians. The purpose of this study was to verify whether this finding can be expanded to the Chinese Han population.

Methods and Results

Using a Chinese Han sample, which consisted of 1012 well-characterized CAD patients and 889 healthy controls, we tested the associations of four SNPs (rs2048327, rs3127599, rs7767084 and rs10755578) in the SLC22A3-LPAL2-LPA gene cluster, and their inferred haplotypes with the risk of CAD. Allelic, genotypic and haplotype association analyses all showed that the gene cluster was not associated with CAD in this Chinese Han sample.

Conclusions

We for the first time explored the association of the four SNPs in the SLC22A3-LPAL2-LPA gene cluster with CAD in a large Chinese Han sample. Nevertheless, this study did not reveal any significant evidence of this gene cluster to increase the risk of CAD in this population.

Keywords:
Association study; CAD; Lp(a); SLC22A3-LPAL2-LPA; SNP