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Open Access Research

Relationship of oxidized low density lipoprotein with lipid profile and oxidative stress markers in healthy young adults: a translational study

Kiriaque BF Barbosa1, Ana Carolina P Volp2, Helen Hermana M Hermsdorff3, Iñigo Navarro-Blasco4, M Ángeles Zulet3, J Alfredo Martínez3 and Josefina Bressan5*

Author Affiliations

1 Nutrition Center, Federal University of Sergipe, Aracaju, Brazil

2 Department of Clinical and Social Nutrition, Federal University of Ouro Preto, Ouro Preto, Brazil

3 Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain

4 Department of Chemistry and Soil Science, Universidad de Navarra, Pamplona, Spain

5 Department of Nutrition and Health, Federal University of Viçosa, Viçosa, Brazil

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Lipids in Health and Disease 2011, 10:61  doi:10.1186/1476-511X-10-61

Published: 19 April 2011

Abstract

Background

Despite oxidized low density lipoprotein (ox-LDL) plays important roles in the pro-inflammatory and atherosclerotic processes, the relationships with metabolic and oxidative stress biomarkers have been only scarcely investigated in young adult people. Thus, the aim of this study was to assess plasma ox-LDL concentrations and the potential association with oxidative stress markers as well as with anthropometric and metabolic features in healthy young adults.

Methods

This study enrolled 160 healthy subjects (92 women/68 men; 23 ± 4 y; 22.0 ± 2.9 kg/m2). Anthropometry, body composition, blood pressure, lifestyle features, biochemical data, and oxidative stress markers were assessed with validated tools. Selenium, copper, and zinc nail concentrations were measured by atomic absorption spectrophotometry.

Results

Total cholesterol (TC), LDL-c and uric acid concentrations, TC-to-HDL-c ratio, and glutathione peroxidase (GPx) activity were positive predictors of ox-LDL concentrations, while nail selenium level (NSL) was a negative predictor, independently of gender, age, smoking status, physical activity. Those individuals included in the highest tertile of GPx activity (≥611 nmol/[mL/min]) and of NSL (≥430 ng/g of nail) had higher and lower ox-LDL concentrations, respectively, independently of the same covariates plus truncal fat or body mass index, and total cholesterol or LDL-c concentrations.

Conclusions

Ox-LDL concentrations were significantly associated with lipid biomarkers, GPx activity, uric acid concentration, and NSL, independently of different assayed covariates, in young healthy adults. These findings jointly suggest the early and complex relationship between lipid profile and redox status balance.