A tracing illustrating the reduced acetylcholine-induced vasorelaxation of a common carotid artery ring that was precontracted using the thromboxane analog U46619 in a male apolipoprotein E-deficient (ApoE) mouse compared with a wild-type C57BL/6J (control) mouse. Both animals were fed a lipid-rich Western-type diet for 26 weeks. Reproduced with permission from d'Uscio et al. .
Meyrelles et al. Lipids in Health and Disease 2011 10:211 doi:10.1186/1476-511X-10-211