Figure 10.

Scheme summarizing the main lipid abnormalities and their consequence to atherosclerosis and to abnormal vascular responsiveness mediated through a NO/ROS imbalance in the apoE-/- mouse. Abbreviations: ADMA, asymmetric dimethyl-L-arginine; BH4, tetrahydrobiopterin; eNOS, endothelial nitric oxide synthase; HDL, High-density lipoprotein; IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein; NADPH, nicotinamide adenine dinucleotide phosphate; NO, nitric oxide; •O2-, superoxide anion; •ONOO-, peroxynitrite; PC, total plasma cholesterol; ROS, reactive oxygen species; TG, triglycerides; VLDL, very-low-density lipoproteins.

Meyrelles et al. Lipids in Health and Disease 2011 10:211   doi:10.1186/1476-511X-10-211
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