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Changes of blood biochemistry in the rabbit animal model in atherosclerosis research; a time- or stress-effect

Ismene A Dontas*, Katerina A Marinou, Dimitrios Iliopoulos, Nektaria Tsantila, George Agrogiannis, Apostolos Papalois and Theodore Karatzas

Lipids in Health and Disease 2011, 10:139  doi:10.1186/1476-511X-10-139

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Halina Malina   (2012-01-05 11:37)  MalinaLab-Axanton email

It is a model of anesthetic product toxicity?

In the title of the article is a lack of the most significant factors, which probably are responsible for the observed changes, the anesthetic products.
It could be a particularly suitable model for the toxicity of the anesthetic products and frequency of their use.
The rabbits were anaesthetized 3 times with 12 mg/kg every month. The third anesthesia did not account for metabolic changes, because they were killed. However, they live for three months after the treatment of anesthetic products (final 72 mg of ketamine per rabbit, 3 kg).
Excellent results showing, how frequency of anesthesia and the use of a small molecule, which lead to protein modification, results in pathology.
There is a lack of information about diet. The source of the proteins in the diet is important.

Competing interests

Malina H. or Malina H.Z. Patents


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